研究方向：

1、药效导向的中药民族药质量标志物研究

2、基于复杂体系分析的药效机制及药效物质基础研究

一、近5年主持承担的科研项目

（1）国家自然科学基金，绞股蓝总皂苷通过调控胆汁酸受体TGR5及FXR改善肝脏免疫炎症的机制研究。

（2）国家自然科学基金，蛋白组学结合代谢组学揭示中药绞股蓝治疗代谢综合征的生物机制。

（3）贵州省科技厅人才项目，贵州省高层次创新型人才（百层次人才）。

（4）贵州省科技厅创新人才团队，贵州省中药民族药质量标志物发现及优势品质研究科技创新人才团队建设。

（5）贵州省科技支撑计划重点项目，贵州铁皮石斛、金钗石斛理化成分及生物学特征研究。

（6）贵州省科技支撑计划项目，贵州仿野生铁皮石斛特色品质挖掘及精准质量标准体系研究。

（7）贵州省科技重大专项，贵州仿野生栽培铁皮石斛优势质量挖掘及全流程质量控制体系建立与示范性应用。

（8）贵州省教育厅服务“四新”“四化”科技攻关项目，贵州金钗石斛优势品质挖掘及推广产学研合作。

（9）贵州省教育厅平台类项目，贵州省高等学校金钗石斛产业发展关键技术工程研究中心。

（10）贵州省教育厅“揭榜挂帅”科技攻关项目，苗药大品种宁泌泰原料、生产及质量提升关键技术攻关。

（11）贵州省优秀青年科技人才项目，基于高通量分析技术的药物作用和毒性机制及质量控制研究。

二、近5年授权的专利及软件著作权

1、已授权发明专利

（1）三萜类化合物及其制备方法与抗炎用途，1/6，何芋岐，谭道鹏，鲁艳柳，秦琳，张倩茹，陆安静，遵义医科大学，国家发明专利，授权，ZL202110903499.7，授权时间：20230718。

（2）一种用于促进睡眠的药物组合物，1/3，何芋岐，龚其海，谭道鹏，遵义医科大学，国家发明专利，授权，ZL202111198856.0，授权时间：20230905。

（3）一种具有保湿功效的金钗石斛多糖及其制备方法及应用，1/7，何芋岐，白朝钧，谭道鹏，鲁艳柳，秦琳，张倩茹，杜艺玫，遵义医科大学，国家发明专利，授权，ZL202010152786.4，授权时间：20210914。

（4）一种具有降血脂功能的中药组合物及其制备方法及应用，1/8，何芋岐，杜艺玫，吴迪，鲁艳柳，秦琳，谭道鹏，凌蕾，陆安静，遵义医学院，国家发明专利，授权，ZL201811447832.2，授权时间：20210706。

（5）一种绞股蓝皂苷侧链寡糖的制备方法，1/4，何芋岐，吴迪，鲁艳柳，吴庆，遵义医科大学，国家发明专利，ZL201710473917.7，授权，授权时间：20201124。

（6）一种用于降血糖的药物组合物，1/6，何芋岐，吴迪，鲁艳柳，杨滔，杜清，吴庆，遵义医科大学，国家发明专利，ZL201710910115.8，授权，授权时间：20201204。

（7）一种含金钗石斛复方中药组合物及其制备方法，2/7，秦琳，何芋岐，谭道鹏，杜艺玫，鲁艳柳，张倩茹，周旭美，遵义医科大学，国家发明专利，ZL201910974417.0，授权，授权时间：20220617。

（8）艾纳香药材中有效成分含量的检测方法，2/5，谭道鹏，何芋岐，秦琳，杜艺玫，鲁艳柳，遵义医科大学，国家发明专利，ZL201910028047.1，授权，授权时间：20210907。

（9）一种治疗或预防冠状病毒感染的药物组合物，2/7，谭道鹏，何芋岐，鲁艳柳，秦琳，杜艺玫，张倩茹，周旭美，遵义医科大学，国家发明专利，ZL202010090724.5，授权，授权时间：20210907。

（10）达玛烷型三萜及其制备方法与用途，2/7谭道鹏，何芋岐，鲁艳柳，秦琳，张倩茹，杨洲，陆安静，遵义医科大学，国家发明专利，ZL 2021 1 0182771.7，授权，授权时间：20230822。

（11）三萜类化合物及其制备方法与用途，2/6 谭道鹏，何芋岐，鲁艳柳，秦琳，张倩茹，陆安静，遵义医科大学，国家发明专利，ZL 2021 1 0830985.0，授权，授权时间：20230822。

（12）艾纳香油中2,4-二羟基-6-甲氧基苯乙酮的含量测定方法，2/6谭道鹏，何芋岐，鲁艳柳，秦琳，杜艺玫，张倩茹，遵义医科大学，国家发明专利，ZL 202010207949.4，授权，授权时间：20220819。

（13）三萜类化合物及其制备方法与平喘用途，2/6 谭道鹏，何芋岐，鲁艳柳，秦琳，张倩茹，陆安静，遵义医科大学，国家发明专利，ZL202110942150.4，授权，申请日：20210817，授权时间：20230718。

（14）一种二茂钴的制备工艺，2/4，赵长阔，何芋岐，王先恒，高磊，遵义医科大学，国家发明专利，遵义医科大学，国家发明专利，ZL201510459114.7，授权时间：20190312。

（15）一种白及切片的制备方法，3/10，徐徳林，张禾，何芋岐，王路，李惠民，向雨鑫，陈江霞，李林，闻伟锷，何毅怀，遵义医科大学，国家发明专利，遵义医科大学，国家发明专利，ZL 202110490966.8，授权时间：20220225。

（16）一种金钗石斛联苄基成分及提取分离和手性拆分方法，6/7，肖世基，成蕾，张茂生，聂绪强，陈永正，何芋岐，张建永，遵义医科大学，国家发明专利，ZL201810959080.1，授权时间：20200526。

（17）一种联苄基二聚体类化合物及其从金钗石斛中提取分离的方法与应用，7/8，肖世基，尚志梅，李晓飞，张茂生，聂绪强，陈永正，何芋岐，张建永，遵义医科大学，国家发明专利，ZL201810898716.6，授权时间：20191112。

（18）老鹰茶中一类新骨架黄烷醇及其分离制备方法，4/4，肖世基，成蕾，张茂生，何芋岐，遵义医科大学，国家发明专利，ZL201710396390.2，授权时间：20190412。

（19）一种木脂素类化合物及其从老鹰茶中提取分离的方法与应用，4/4，肖世基，成蕾，张茂生，何芋岐，遵义医科大学，国家发明专利，ZL201810907352.3，授权时间：20190412。

2、获软件著作权1项

（1）铁皮石斛仿野生种植智能追溯系统，何芋岐，谭道鹏，鲁艳柳，张倩茹，秦琳，陆安静，谢健，登记号：2021SR2001224，发表日期：20210920。

三、近5年获得的科技奖项

（1）何芋岐（1/1），第十六届贵州省青年科技奖，2022.03。

（2）何芋岐（1/9），贵州医学科技奖一等奖，贵州道地药材金钗石斛优势物质基础及品质挖掘推动乡村振兴产业示范，2022.12

（3）何芋岐（1/1），2019年西部药学之星，2019.5

（4）何芋岐（3/6），贵州医学科技奖三等奖，黔产中药抗糖尿病及其皮肤并发症的作用及机制研究，2022.12

(1) Di Wu, Lin Qin Chengcheng Feng, Ligang Cao, Ju Ye, Xingdong Wu, Daopeng Tan*, Yuqi He*. Sesquiterpenoids of Dendrobium nobile Lindl. aqueous extract for inhibition alcoholic liver injury through RTK/ELF4regulated inflammation in mouse hepatic macrophages, Arabian Journal of Chemistry, 2024,17: 105501

(2) Jian Xie, Mingxia Luo, Qiuyi Chen, Qianru Zhang, Lin Qin, Yuhe Wang, Yongxia Zhao*, Yuqi He**. Hypolipidemic effect and gut microbiota regulation of Gypenoside aglycones in rats fed a high-fat diet. Journal of Ethnopharmacology, 2024.

(3) Yi Luo†, Da Yang†, Yanzhe Xu, Di Wu, Daopeng Tan, Lin Qin, Xingdong Wu, Yanliu Lu,* and Yuqi He,* Hypoglycemic effects and quality markers screening of Den-drobium nobile Lindl. at different growth years. Molecules, 2024.

(4) Yanzhe Xu, Miao Wang, Yi Luo, Hao Liu, Hua Ling, Yuqi He**, Yanliu Lu*, PPARα is one of the key targets for dendrobine to improve hepatic steatosis in NAFLD. Journal of Ethnopharmacology, 2024, 323: 117684

(5) Yongxia Zhao, Xiaolong Ji, Xiaoqi Liu, Lin Qin, Daopeng Tan, Di Wu, Chaojun Bai, Jiyong Yang, Jian Xie*, Yuqi He*. Age-dependent dendrobine biosynthesis in Dendrobium nobile: insights into endophytic fungal interactions. Frontiers In Microbiology, 2023, 14:1294402.

(6) Ligang Cao, Di Wu, Lin Qin, Daopeng Tan, Qingjie Fan, Xiaohuan Jia, Mengting Yang, Tingting Zhou, Chengcheng Feng, Yanliu Lu, Yuqi He*. Single-Cell RNA Transcriptome Profiling of Liver Cells of Short-Term Alcoholic Liver Injury in Mice. International Journal of Molecular Sciences. 2023, 24(5): 4344.

(7) Peiqi Liu, Qian Li, Guanghao Zhu, Tiantian Zhang, Dongzhu Tu, Feng Zhang, Moshe Finel, Yuqi He**, Guangbo Ge*, Characterization of the glucuronidating pathway of pectolinarigenin, the major active constituent of the Chinese medicine Daji, in humans and its influence on biological activities. J Ethnopharmacol. 2023 Oct 4; 319(Pt 1): 117280. doi: 10.1016/j.jep.2023.117280.

(8) Ju Ye, Di Wu, Xingdong Wu Lin Qin, Mengting Yang, Yan-liu Lu, Dao-peng Tan, Yu-qi He,* Dendrobium officinale aqueous extract regulates bile acid synthesis to improve acute alcoholic liver injury in mice. Food Bioscience, 2023 ,55 (2023) 103087

(9) Mengting Yang, Qianru Zhang, Anjing Lu, Zhou Yang, Daopeng Tan, Yanliu Lu, Lin Qin*, Yu-qi He*. The preventive effect of secondary metabolites of Dendrobium officinale on acute alcoholic liver injury in mice. Arabian Journal of Chemistry, Volume 16, Issue 10, October 2023, 105138

(10) Daopeng Tan, Lei Ling, Lin Qin, Yanliu Lu, Di Wu, Yuqi He*. Rosiglitazone induces hepatocyte injury by increasing DCA accumulation through OATP1A4 inhibiting in mice. Arabian Journal of Chemistry, Volume 16, Issue 10, October 2023, 105142

(11) Xianmei Gou, Lin Qin, Di Wu, Jian Xie, Yanliu Lu, Qianru Zhang*, Yuqi He*. Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome. Molecules. 2023 Aug 4; 28(15): 5870. doi: 10.3390/molecules28155870.

(12) Chengcheng Feng, Yanping Yang, Anjing Lu, Daopeng Tan, Yanliu Lu, Lin Qin, Yuqi He*. Multi‑omics‑based analysis of the regulatory mechanism of gypenosides on bile acids in hypercholesterolemic mice. Experimental and Therapeutic Medicine. 2023 Jul 31;26(3):438. doi: 10.3892/etm.2023.12136.

(13) Tingting Zhou, Ligang Cao, Yimei Du, Lin Qin, Yanliu Lu, Qianru Zhang, Yuqi He*, Daopeng Tan*. Gypenosides ameliorate high-fat diet-induced nonalcoholic fatty liver disease in mice by regulating lipid metabolism. PeerJ. 2023 Apr 11;11:e15225. doi: 10.7717/peerj.15225.

(14) Jian Xie, Qiuyi Chen, Yongxia Zhao, Mingxia Luo, Xin Zeng, Lin Qin, Daopeng Tan*, Yuqi He*. Transcriptome Sequencing Reveals Autophagy Networks in Rat Livers during the Development of NAFLD and Identifies Autophagy Hub Genes. International Journal of Molecular Sciences. 2023 Mar 29;24(7):6437. doi: 10.3390/ijms24076437.

(15) Yongxia Zhao, Lin Qin, Daopeng Tan, Di Wu, Xingdong Wu, Qingjie Fan, Chaojun Bai, Jiyong Yang, Jian Xie*, Yuqi He*. Fatty acid metabolites of Dendrobium nobile were positively correlated with representative endophytic fungi at altitude. Frontiers In Microbiology. 2023 Apr 27;14:1128956. doi: 10.3389/fmicb.2023.1128956.

(16) Bo-Yan Luo, Hong-Su Zhou, Yi-Fei Sun, Qiu-Xia Xiao, Li Chen, Hong-Qing She, Shi-Feng Wang, Shan-Shan Yan, Quan-Yuan Chang, Yu-Qi He*, Liu-Lin Xiong*. The fate and prospects of stem cell therapy in the treatment of hypoxic-ischemic encephalopathy. European Journal Of Neuroscience. 2023 May 9. doi: 10.1111/ejn.16040.

(17) Daopeng Tan, Jianmei Wang, Ligang Cao, Da Yang, Yanliu Lu, DiWu, Yongxia Zhao, Xingdong Wu, Qingjie Fan, Zhou Yang, Lin Qin*, Yuqi He*. UDP-glycosyltransferases play a crucial role in the accumulation of alkaloids and sesquiterpene glycosides in Dendrobium nobile, Arabian Journal of Chemistry, 2023, 16: 104673.

(18) Da Yang, Yeyang Song, Anjin Lu, Lin Qin, Daopeng Tan, Qianru Zhang, Yuqi He * and Yanliu Lu*. Metabolomics-Based Analysis of the Effects of Different Cultivation Strategies on Metabolites of Dendrobium officinale Kimura et Migo. Metabolites 2023, 13, 389.

(19) Wenjing Yang, Dengwang Chen, Qinglu Ji, Jishan Zheng, Yunyan Ma, Hongqin Sun, Qian Zhang, Jidong Zhang*, Yuqi He*, Tao Song*. Molecular mechanisms underlying the anticancer property of Dendrobium in various systems of the human body: A review. Biomed Pharmacother. 2023 Sep;165:115223. doi: 10.1016/j.biopha.2023.115223.

(20) Xiaohuan Jia, Faming Wu, Anjing Lu, Daopeng Tan, Qianru Zhang, Yuqi He*, Lin Qin*. Widely Targeted Metabolomics Analysis of Dendrobium officinale at Different Altitudes. chemistry & biodiversity. 2023, 3: e202201082.

(21) Daopeng Tan, Lin Qin, Jianmei Wang, Chunxue Gao, Yanliu Lu, Zhou Yang, Yuqi He*, Sesquiterpene glycosides from Dendrobium nobile and their chemotaxonomic significance[J]. Biochemical Systematics and Ecology, 2023, 106: e104541.

(22) Zunping Wu, Yanzhe Xu, Ruoyu Zhou, Hao Liu, Hua Ling, Yimei Du, Yanliu Lu* and Yuqi He*. Gypenosides Improve Lipid Homeostasis by Regulating Fatty Acid Metabolism in the Liver, Current Topics in Nutraceutical Research, 2023, 21(01): 1-7.

(23) Juan Chen, Lin Qin , Xingdong Wu, Daopeng Tan, Yanliu Lu , Yimei Du, Di Wu , Yuqi He*. Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences. International Journal of Molecular Sciences. 2023, 11; 24(2): 1454. doi: 10.3390/ijms24021454.

(24) Li Chen, Lu Chen, Xu Li, Lin Qin, Yan Zhu, Qianru Zhang, Daopeng Tan, Yuqi He*, Yu-He Wang*. Transcriptomic profiling of hepatic tissues for drug metabolism genes in nonalcoholic fatty liver disease: A study of human and animals. Front Endocrinol (Lausanne). 2023, 4, 13: 1034494. doi: 10.3389/fendo.2022.1034494.

(25) Qianqian He, Anjing Lu, Lin Qin, Qianru Zhang, Yanliu Lu, Zhou Yang, Daopeng Tan*, Yuqi He*. An UPLC-Q-TOF/MS-Based Analysis of the Differential Composition of Dendrobium officinale in Different Regions. Journal of Analytical Methods in Chemistry. 2022 Nov 4; 2022: 8026410. doi: 10.1155/2022/8026410

(26) Jing Liu†, Qinglu Ji†, Feng Cheng†, Dengwang Chen†, Tingting Geng, Yueyue Huang, Jidong Zhang*, Yuqi He* and Tao Song*. The lncRNAs involved in regulating the RIG-I signaling pathway. Frontiers in Cellular and Infection Microbiology, 2022, Nov 9;12:1041682

(27) Anjing Lu, Ligang Cao, Daopeng Tan, LinQin, Yanliu Lu, Yongxia Zhao, Yong Qian, Chaojun Bai, Ji-yong Yang, Hua Ling, Jing-shan Shi, Zhou Yang, Yuqi He*, UPLC-Q/TOF-MS coupled with multivariate analysis for comparative analysis of metabolomic in Dendrobium nobile from different growth altitudes. Arabian Journal of Chemistry, 2022

(28) Juan Chen, Anjing Lu, Daopeng Tan, Qianru Zhang, Yanliu Lu, Lin Qin, and Yuqi He*. Determination of Scopolamine Distribution in Plasma and Brain by LC-MS/MS in Rats. International Journal of Analytical Chemistry, 2022, Article ID 8536235, https://doi.org/10.1155/2022/8536235

(29) Lin Li, Chaobo Liu, Wei'e Wen, Qingqing Li, Tiantian Pan, Zhaogao Li, Gang Qian*, Yuqi He*, Delin Xu*. Dendrobine biosynthesis in Dendrobium nobile in four different habitats is affected by the variations in the endophytic fungal community. Frontiers in Microbiology 2022; 13: 981070. doi: 10.3389/fmicb.2022.981070.

(30) Qingqing Li†, Chaobo Liu†, Ceyin Huang, Mufei Wang, Teng Long, Jingyi Liu, Junhua Shi, Junli Shi, Lin Li, Yuqi He* and De-Lin Xu*. Transcriptome and Metabonomics Analysis Revealed the Molecular Mechanism of Differential Metabolite Production of Dendrobium nobile Under Different Epiphytic Patterns. Front. Plant Sci, 2022, 13: 868472. https://doi.org/10.3389/fpls.2022.868472

(31) Yuan Jiang, Lin Qin, Anjing Lu, Juan Chen, Jianmei Wang, Qianru Zhang, Yanliu Lu, Qihai Gong, Jianmei Gao, Hong Ma, Daopeng Tan*, Yuqi He*. CYP3A1 metabolism-based neurotoxicity of strychnine in rat. Toxicology. 2022, 471:153156. doi: 10.1016/j.tox.2022.153156. Online ahead of print.

(32) Anjing Lu^#, Yuan Jiang^#, Jia Wu, Dao-peng Tan, Lin Qin, Yan-liu Lu, Yong Qian, Chao-jun Bai, Ji-yong Yang, Hua Ling, Jing-shan Shi, Zhou Yang*, Yu-qi He*. Opposite trends of glycosides and alkaloids in Dendrobium nobile of different age based on UPLC-Q/TOF-MS combined with multivariate statistical analyses. Phytochemical Analysis. 2022, 33(4): 619-634. doi:10.1002/pca.3115

(33) Gang Li, Xinyu Gao, Guifang Qin, Jie Lei, Yongmei Jiang, Lang Linghu, Chengjiang Zhang, Jianyong Zhang, Yongling Wang, Mei Wang, Changwei Song, Yuqi He*, Gang Wang*. Purification of biflavonoids from Selaginelladoe derleinii Hieron by special covalent organic polymers material. Journal of Chromatography A. 2022 Feb 26; 1668: 462920.

(34) An-Jing Lu, Yan-Liu Lu, Dao-Peng Tan, Lin Qin, Hua Ling, Chang-Hong Wang*, and Yu-Qi He*. Identification of Pyrrolizidine Alkaloids in Senecio Plants by Liquid Chromatography-Mass Spectrometry. Journal of Analytical Methods in Chemistry, 2021, Article ID 1957863.

(35) Daopeng Tan, Geng Li, Wenying Lv, Xu Shao, Xiaoliang Li, Haijun Niu, Yaoqing Xu, Jianyong Zhang, Lin Qin, Yuqi He*, Min Jiang* and Long Cheng*, Distribution, Metabolism, Excretion and Toxicokinetics of Vitexin in Rats and Dogs, Current Pharmaceutical Analysis 2022; 18(5) :553-564. https://doi.org/10.2174/1573412917666210809154537

(36) Qiang Lu, Daopeng Tan, Yifei Xu, Meigui Liu, Yuqi He*, Cailan Li*. Inactivation of Jack Bean Urease by Nitidine Chloride from Zanthoxylum nitidum: Elucidation of Inhibitory Efficacy, Kinetics and Mechanism. J Agric Food Chem. 2021, 24; 69(46):13772-13779. d

(37) Lian He, Anjing Lu, Lin Qin, Qianru Zhang, Hua Ling, Daopeng Tan*, Yuqi He*, Application of single-cell RNA sequencing technology in liver diseases: a narrative review. The Annals of Translational Medicine, 2021; 9(20): 1598

(38) Yue Bai, Lu Chen, Yun-Feng Cao, Xu-Dong Hou, Shou-Ning Jia, Qi Zhou, Yu-Qi He*, Jie Hou*. Beta-Glucuronidase Inhibition by Constituents of Mulberry Bark. Planta Medica, 2021 Mar 17. doi: 10.1055/a-1402-6431.

(39) Mengting Yang, Daopeng Tan, Anjing Lu, Lin Qin, Changhong Wang, Hua Ling, Yanliu Lu*, Yuqi He*. Identification and simultaneous determination of the main toxical pyrrolizidine alkaloids in a compound prescription of Traditional Chinese Medicine: Qianbai biyan Tablet. International Journal of Analytical Chemistry, 2021, e5209618. DOI: https://doi.org/10.1155/2021/5209618.

(40) Xuqiang Nie*, Jiufeng Zhao, Hua Ling, Youcai Deng, Xiaohui Li*, Yuqi He*. Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential. British Journal of Pharmacology. 2020;177(18):4077-95.

(41) Yongmei Jiang, Sen Wang, Ming Yu, Di wu, Jie Lei, Weiwei Li, Yuqi He* and Wang Gang*. Ultrasonic-assisted ionic liquid extraction of Two Biflavonoids from Selaginella tamariscina. ACS Omega. 2020, 5(51):33113-33124.

(42) Hao Liu, Yixin Zhang, Kaijun Long, Fandi Wang, Xingxing Zeng, Yuanfu Lu, Yuqi He*, and Yanliu Lu*. The metabolomics study revealing the role of Dendrobium nobile Lindl. in the lipid metabolism at physiological status of rats. Current Topics in Nutraceutical Research, 2021, 19(03): 1-7.

(43) Yuqi He, Tao Yang, Yimei Du, Lin Qin, Feifei Ma, Zunping Wu, Hua Ling, Li Yang, Zhengtao Wang, Qingdi Zhou, Guangbo Ge*, Yanliu Lu*. High fat diet significantly changed the global gene expression profile involved in hepatic drug metabolism and pharmacokinetic system in mice. Nutrition & Metabolism, 2020, 17: 37.

(44) Daopeng Tan, Zhou Yang, Qianru Zhang, Hua Ling, Yimei Du, Yanliu Lu, Tianpei Xie, Xumei Zhou, Lin Qin*, and Yuqi He*，Simultaneous Quantitative Determination of Polyphenolic Compounds in Blumea balsamifera (Ai-Na-Xiang, Sembung) by High-Performance Liquid Chromatography with Photodiode Array Detector. International Journal of Analytical Chemistry, 2020, 2020: e9731327.

(45) Yanliu Lu, Yimei Du, Lin Qin, Di Wu, Wei Wang, Lei Ling, Feifei Ma, Hua Ling, Li Yang, Changhong Wang, Zhengtao Wang, Xumei Zhou*, Yuqi He*, Gypenosides Altered Hepatic Bile Acids Homeostasis in Mice Treated with High Fat Diet. Evid Based Complement Alternat Med, 2018: e8098059.

(46) Xuqiang Nie, Huaihong Chen, Jianyong Zhang, Yujing Zhang, Jianwen Yang, Huijun Pan, Wenxia Song, Ferid Murad, Yuqi He*, Ka Bian*. Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways. Acta Pharmacologica Sinica, 2016. 37 (4): 483-96.

贵州省中药民族药质量标志物发现及优势品质研究科技创新人才团队负责人，担任遵义医科大学贵州省药用兰科植物工程研究中心、贵州金钗石斛产业发展关键技术工程研究中心主任。