开展医用光学诊疗技术与创新药物研发。研究方向：
1.光学诊疗剂研发及诊疗性能研究
2.光精准控释给药研究
3.光疗协同化疗抗肿瘤药物研发

教研项目

1. 贵州省首批“三全育人”综合改革试点项目；
   

2. 贵州省课程思政项目；

3. 贵州省高等学校金师项目；

教研成果

1.2021年获贵州省自然科学三等奖，排名1；

2.2023年获贵州省自然科学三等奖，排名5；

3.2022年获第十届贵州省高等教育成果奖一等奖，排名1；

4.2021年获第四届贵州省研究生教学成果一等奖，排名2；

5.2022年获遵义医科大学本科生教学成果一等奖，排名1；

6.2021年获遵义医科大学研究生教学成果特等奖，排名1；

7.2018年获第二届全国医药院校药学/中药学实验教学改革大赛一等奖，排名1；

8.2016年贵州省第五届优秀成果奖,排名1；

9.2015年获遵义市创新成果三等，排名1；

10.2012年获遵义市科技进步二等奖，排名1；

112024年遵义医科大学本科生教学成果特等奖，排名1.

[1]Jie Gao*, Shangli Din, Ling Chen , Hongyu Li, WenChao Geng* , DongSheng Guo**, Zeli Yuan*.Supramolecular photothermal agents mediated by black hole hosts[J].Nano Today,2024,59 :102520.(IF=13.0)

[2]Jiajia Lv, Jie Gao, Hongyu Li, Zeli Yuan*, Nan Dong*.Rational design of hydroxyl tricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo[J].Chinese Chemical Letters,2024,35:108940(IF=9.20).

[3]Yumei Wu, Chunhua Zeng, Jiajia Lv, Hongyu Li, Jie Gao , Zhidong Liu*, Zeli Yuan*.Tumor-Targeted cRGD-Coated Liposomes Encapsulating Optimized Synergistic Cepharanthine and IR783 for Chemotherapy and Photothermal Therapy[J].International Journal of Nanomedicine, 2024:19 6145.

[4]Zhengjun Chen, Yan Liu, Chunhua Zeng, Changyue Ren, Hongyu Li, Rajenahally V. Jagadeesh*, Zeli Yuan*,Xinmin Li*. Borylation of phenols using sulfuryl fluoride activation[J]. Green. Chemistry,2023,25,7998(IF=9.8)

[5] Yan An, Xue Luo, Shuangshuang Wei, Jiajia Lv, Jie Gao, Xinmin Li, Mingyan Yang, Junjun Luo, Yumei Wu, Gang Wei*, Zeli Yuan*, Hongyu Li*. A dual-functional fluorescence probe for detection of Aβ aggregates and hydroxyl radicals[J]. Sensors and Actuators: B. Chemical,2023,397,134653(IF=8.8)

[6] Jie Gao*,Tianjiao Luan, Jiajia Lv, Mingyan Yang, Hongyu Li, Zeli Yuan*. An oxygen-carrying and lysosome-targeting BODIPY derivative for NIR bioimaging and enhanced multimodal therapy against hypoxic tumors[J].J.Photochem. Photobiol. B,2023,241,112666.(IF=5.4)

[7]Jiajia Lv, Jie Gao, Hongyu Li, Zeli Yuan*, Nan Dong*.Rational design of hydroxyl tricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo[J].Chinese Chemical Letters,2024,35:108940(IF=9.20).

[8]Ying Chen, ZhiweiHu, MingyanYang, JieGao, JunjunLuo, HongyuLi*, ZeliYuan*.Monitoring the Different Changing behaviors of •OH and Cysteine in Two Ferroptosis Pathways by a Dual-Functional Fluorescence Probe[J].Sensors and Actuators B: Chemical,2022,131742.(IF=9.1)

[9]Jie Gao,Zhengjun Chen,Xinmin Li, Mingyan Yang, Jiajia Lv, Hongyu Li , Zeli Yuan. Chemiluminescence in Combination with Organic Photosensitizers: Beyond the Light Penetration Depth Limit of Photodynamic Therapy[J]. Int. J. Mol. Sci., 2022, 23, 12556(IF)

[10]Jia-jia Lv, Wen-ting Song, Xin-min Li , Jian-mei Gao* ,Ze-li Yuan*.Synthesis of a New Phenyl Chlormethine-Quinazoline Derivative, a Potential Anti-Cancer Agent, Induced Apoptosis in Hepatocellular Carcinoma Through Mediating Sirt1/ Caspase 3 Signaling Pathway[J].Frontiers in Pharmacology,2020,11,911. (IF=5.6)

[11] Xiaofang Qu, Fuming Yuan, Zhiquan He, Yuhan Mai, Jianmei Gao, Xinmin Li, Dezhi Yang,Yaping Cao, Xiaofei Li*,ZeLiYuan*. A rhodamine-based single-molecular theranostic agent for multiplefunctionality tumor therapy[J].Dyes and Pigments.,2019, 166: 72. (IF=5.12)

[12] Yuhan Mai, Xiaofang Qu, Shangli Ding, Jiajia Lv, Xinmin Li, Pengyuan Gao, Yun Liu,Zeli^*Yuan. Improved IR780 derivatives bearing morpholine group as tumor-targeted therapeutic agent for near-infrared fluorescence imaging and photodynamic therapy.Dyes and Pigments.,2020, 177,107979e. (IF=5.12)

  团队由校内校外导师和澳大利亚导师构成，依托贵州省医用光学诊疗技术研究国际科技合作基地，为贵州省教育厅医用光学诊疗创新团队，遵义医科大学优秀研究生创新团队。现有成员12人，其中博士11人，在读博士1人。