聂绪强，教授，博士生导师。上海中医药大学中药学专业博士（师从诺贝尔奖获得者Ferid Murad教授及美国斯坦福大学医学院Bian Ka教授），中国人民解放军第三军医大学（陆军军医大学）药学博士后。先后在香港中文大学（CUHK）、澳大利亚昆士兰科技大学（Queensland University of Technology，QUT）、昆士兰大学（University of Queensland，UQ）做访问学者。现任遵义医科大学首批生必赢nn699net带头人、学科负责人、生药学教研室主任、 “南山班”导师，贵州省千层次创新型人才、贵州省优秀青年科技人才。
中国药理学会抗炎免疫药理专业委会委员、中国老年学和老年医学学会抗衰老分会委员、中国民族医药学会外科分会理事、中国微循环学会转化医学专业委员会委员、澳洲华人生物医学协会会员（ACABS）、中国植物学会药用植物及植物药专业委员会会员、贵州省药学会药学教育与科普专业委员会副主任委员，国家自然科学基金医学部项目及教育部学位论文评审专家等。Frontiers in Immunology客座主编，World Journal of Diabetes编委，Burns & Trauma、Journal of Diabetes、Chinese Herbal Medicines、Metabolism and Target Organ Damage、《遵义医科大学学报》等杂志青年编委；Nature Communications、Diabetes、Clinical Immunology等30余本SCI期刊审稿人。
先后主持国家自然科学基金4项、省部级课题等8项。在国内外期刊发表论文80余篇，其中J Adv Res、Acta Pharmacol Sin、Burns & Trauma、Brit J Pharmacol等SCI收录40余篇。获“中国精品科技期刊顶尖学术论文”领跑者5000（F5000）论文奖、“挑战杯”大学生创业计划竞赛全国铜奖、贵州省大学生创业大赛二等奖、贵州省医学科技三等奖、遵义医科大学优秀研究生导师等荣誉。
主要研究方向为：内分泌代谢性疾病发病新机制和天然药物防治新靶标研究。
科研成果：先后主持国家自然科学基金4项，贵州省基础研究重点项目、贵州省科技重大专项、贵州省优秀青年人才项目、重庆市博士后特别资助等省部级课题8项, 市厅级课题10项，参与国家科技重大新药创制计划2项。在国内外期刊发表论文80余篇，其中《中草药》《中国中药杂志》《中国药学杂志》等北大中文核心期刊25篇，J Adv Res、Acta Pharmacol Sin、Burns Trauma、Brit J Pharmacol、Food Res Int、Int J Biol Macromol、Front Immunol、J Ethnopharmacol等中科院2区以上SCI杂志收录30余篇。以第一排名获得“中国精品科技期刊顶尖学术论文”领跑者5000（F5000）论文奖、“挑战杯”全国大学生创业计划竞赛全国铜奖、贵州省大学生创业大赛二等奖、贵州省医学科技奖三等奖等。
l Wu X, Gu R, Tang M, Mu X, He W, Nie X*. Elucidating the Dual Roles of Apoptosis and Necroptosis in Diabetic Wound Healing: Implications for Therapeutic Intervention. Burns & Trauma, 2024 Aug 28, 12:tkae061. doi: 10.1093/burnst/tkae061
l Chen J, Deng J, Tang M, Nie X*. Asiaticoside-Nitric Oxide Hydrogel accelerates diabetic wound healing via miR-21-mediated DNA demethylation. Asian Journal of Surgery, 2024 Sep 28:S1015-9584(24)02152-3. PMID: 39343674
l Tang Y, Gu R, Rong J, Nie X*. Bibliometric Analysis of ncRNA Studies in Diabetes Mellitus with Coronary Heart Disease: A Visualization Approach. Clinical Medicine Insights: Endocrinology and Diabetes, 2024 Sep 27, 17: 11795514241276389. PMID: 39371961
l Mu X, Gu R, Tang M, Wu X, He W, Nie X*. IL-17 in wound repair: bridging acute and chronic responses. Cell Communication and Signaling, 2024, 22(1):288. PMID: 38802947
l He W, Tang M, Gu R, Wu X, Mu X, Nie X*. The Role of p53 in Regulating Chronic Inflammation and PANoptosis in Diabetic Wounds. Aging and Disease, 2024 Feb 19. Online ahead of print. PMID: 38377027
l He W, Mu X, Wu X, Liu Y, Deng J, Liu Y, Han F, Nie X*. The cGAS-STING Pathway: A Therapeutic Target in Diabetes and Its Complications. Burns & Trauma, 2024 Feb 2,12:tkad050. PMID: 38312740
l Pang H, Wu Y, Chen Y, Chen C, Nie X, Li P, Huang G, Xu ZP*, Han FY*. Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery. Drug Delivery and Translational Research, 2024 Jan 12. Online ahead of print. PMID: 38214820
l Liu Y, Zhao J, Mu X, Deng J, Wu X, He W, Liu Y, Gu R, Felicity H, Nie X*. Asiaticoside-Nitric Oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway. Journal of Ethnopharmacology, 2024, 319:117266. PMID: 37783408
l Ye P, Gu R, Zhu H, Chen J, Felicity H, Nie X*. SOX Family Transcription Factors as Therapeutic Targets in Wound Healing: A Comprehensive Review. International Journal of Biological Macromolecules, 2023,253:127243. PMID: 37806414
l Deng J, Wu X, He W, Liao X, Tang M*, Nie X*. Targeting DNA Methylation and Demethylation in Diabetic Foot Ulcers. Journal of Advanced Research, 2023, 54:119-131. PMID: 36706989
l Zhu H, He W, Ye P, Chen J, Wu X, Mu X, Wu Y, Pang H, Felicity H, Nie X*. Piezo1 in Skin Wound Healing and Related Diseases: Mechanotransduction and Therapeutic Implications. International Immunopharmacology, 2023, 123:110779. PMID: 37582313
l Liang Z#, Chen Y#, Gu R, Guo Q, Nie X*. Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway. Current Molecular Medicine, 2023, 23(10):1116 -1129. PMID: 36284389
l Tang M*, Suraweera A, Nie X, Li Z, Lai P, Wells JW, O'Byrne KJ, Woods RJ, Bolderson E*, Richard DJ*. Mono-phosphorylation at Ser4 of barrier-to-autointegration Factor (Banf1) significantly reduces its DNA binding capability by inducing critical changes in its local conformation and DNA binding surface. Physical Chemistry Chemical Physics, 2023, 25(36):24657-24677. PMID: 37665626
l Liu Y, Lin M, Mu X, Qin L, Deng J, Liu Y, Wu X, He W, Pang H, Felicity H, Sun C, Nie X*. Protective effect of solanesol in glucose-induced hepatocyte injury: Mechanistic insights on oxidative stress and mitochondrial preservation. Chemico-Biological Interactions, 2023, 383:110676. PMID: 37586544
l Chen J, Ye P, Gu R, Zhu H, He W, Mu X, Wu X, Pang H, Felicity H, Nie X*. Neuropeptide Substance P: A Promising Regulator of Wound Healing in Diabetic Foot Ulcers. Biochemical Pharmacology, 2023, 215:115736. PMID: 37549795
l Yuan Y, Liu R, Gu R, Nie X*. Impact of 17β-Estradiol on Vascular Function in Ovariectomized Rats with Diabetes Mellitus. Asian Journal of Surgery, 2023, 46(11):5277-5279. PMID: 37474384
l Yuan Y, He J, Tang M, Chen H, Wei T, Zhang B, Liang D, Nie X*. Preventive Effect of Ya'an Tibetan Tea on Obesity in Rats Fed with a Hypercaloric High-fat diet Revealed by Gut Microbiology and Metabolomics Studies. Food Research International, 2023,165:112520. PMID: 36869524
l Yuan Y, He J, Wei T, Zhang B, Liu D, Yang W, Guo C, Nie X*. Combinations of Tibetan tea and medicine food homology herbs: A new strategy for obesity prevention. Food Science & Nutrition, 2022, 11(1): 504-515. PMID: 36655078
l Wu X, He W, Mu X, Liu Y, Deng J, Liu Y, Nie X*. Macrophage Polarization in Diabetic Wound Healing. Burns & Trauma, 2022, 10, tkac051:1-13. PMID: 36601058
l Li W, Mu X, Wu X, He W, Liu Y, Liu Y, Deng J, Nie X*. Dendrobium nobile Lindl. Polysaccharides Protect Fibroblasts Against UVA-Induced Photoaging via JNK/c-Jun/MMPs Pathway. Journal of Ethnopharmacology, 2022, 298:115590. PMID: 35973631
l Mu X, Wu X, He W, Liu Y, Wu F, Nie X*. Pyroptosis and Inflammasomes in Diabetic Wound Healing. Frontiers in Endocrinology, 2022, 13:950798. PMID: 35992142
l Liu Y, Liu Y, He W, Mu X, Wu X, Deng J, Nie X*, Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing. Frontiers in Immunology, 2022, 13: 918223. PMID: 35990622
l Liu Y#, Zhang D#, Deng J, Liu Y, Li W, Nie X*. Preparation and Safety Evaluation of Centella Asiatica Total Glycosides Nitric Oxide Gel and its Therapeutic Effect on Diabetic Cutaneous Ulcers. Evidence-Based Complementary and Alternative Medicine, 2022, 2022: 1419146. PMID: 35368764
l Deng J, Liu Y, Liu Y, Li W, Nie X*. The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy. Journal of Inflammation Research, 2021,14:5273-5290. PMID: 34703268
l Liu Y, Liu Y, Deng J, Li W, Nie X*. Fibroblast Growth Factor in Diabetic Foot Ulcer: Progress and Therapeutic Prospects. Frontiers in Endocrinology, 2021,12:744868. PMID: 34721299
l Liu Y, Deng J, Liu Y, Li W, Nie X*. FGF, Mechanism of Action, Role in Parkinson’s Disease, and Therapeutics. Frontiers in Pharmacology, 2021, 12:675725. PMID: 34234672
l Nie X*, Zhao J, Ling H, Deng Y, Li X*, He Y*. Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential. British Journal of Pharmacology, 2020, 177(18):4077-4095. PMID: 32449793
l Nie X#*, Zhang H#,Shi X, Zhao J, Yang J，Li X*. Asiaticoside Nitric Oxide Gel Accelerates Diabetic Wound Healing by Activating Wnt/β-Catenin Signaling Pathways. International Immunopharmacology, 2020,79:106109. PMID: 31865242
l Li W, Chen Y, Nie X*.Regulatory mechanisms of lncRNAs and their target gene signaling pathways in laryngeal squamous cell carcinoma. Frontiers in Pharmacology, 2020, 11:1140. PMID: 32848755
l Nie X*, Chen Y, Li W, Lu Y. Anti-aging Properties of Dendrobium nobile Lindl.: From molecular mechanisms to potential treatments. Journal of Ethnopharmacology, 2020, 257:112839. PMID: 32268205
l Mo X, Liu W, Yang Y, Imani S, Lu S, Dan G, Nie X, Yan J, Zhan R, Li X, Deng Y*, Chen B*, Cai Y*. NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis. Journal of Cellular Biochemistry, 2019, 120(10):1-17. PMID: 31245869
l Zhang H, Nie X*, Shi X, Zhao J, Chen Y, Yao Q, Sun C, Yang J. Regulatory Mechanisms of the Wnt/β-Catenin Pathway in Diabetic Cutaneous Ulcers. Frontiers in Pharmacology, 2018, 9:1114. PMID: 30386236
l Deng Y#*, Song L#, Nie X, Shou W, Li X*. Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention. Pharmacology & Therapeutics, 2018, 190:159-172. PMID: 29803628
l Yang Y, Lu Q, Shao X, Mo B, Nie X, Liu W, Chen X*, Tang Y*, Deng Y*, Yan J*. Development Of A Three-Gene Prognostic Signature For Hepatitis B Virus Associated Hepatocellular Carcinoma Based On Integrated Transcriptomic Analysis. Journal of Cancer, 2018, 9(11):1989-2002. PMID: 29896284
l Zhang L*, Liu L, Zheng C, Wang Y, Nie X, Shi D, Chen Y, Wei G, Wang J*. Synthesis and biological evaluation of novel podophyllotoxin-NSAIDs conjugates as multifunctional anti-MDR agents against resistant human hepatocellular carcinoma Bel-7402/5-FU cells. European Journal of Medicinal Chemistry, 2017, 131:81-91. PMID: 28301815
l Zhang L*, Li W, Liu L, Zheng C, Wang Y, Xu Y, Shi D, Nie X, Guo J, Zhu C,Wang J*. Synthesis of novel pyrazole derivates containing isatins as potential apoptosis inducer in non-small lung cancer A549 cells. Chinese Journal of Organic Chemistry, 2017,37:1721-1729.
l Nie X, Chen H, Zhang J, Zhang Y, Yang J, Pan H, Song W, Murad F, He Y*, Bian K*. Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways. Acta Pharmacologica Sinica, 2016, 37(04):483-496. PMID: 26972495
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