1，中药活性成分（多糖等）的提取纯化，结构鉴定，及其在治疗肥胖、糖尿病、肿瘤和免疫疾病等疾病中的应用研究；

 2，纳米技术在基因递送治疗肥胖、糖尿病和自身免疫疾病等疾病中的应用研究；

 3，肥胖、糖尿病和自身免疫疾病等疾病的发病机制研究；

1. 一种微量透析装置 实用新型 授权

2. 党参中过氧白术内酯Ⅲ的提取分离方法及其应用 发明 授权

3. 一种从老鹰茶中提取二聚呋喃酮类化合物的方法及其应用 发明 授权

4. 一种绞股蓝中性多糖及其提取方法和抗新冠病毒的应用 发明 授权

5. 一种杜仲酸性多糖、提取方法及其在制备抗结肠癌药物中的应用 发明 授权

6. 一种杜仲酸性多糖、提取方法及其在制备治疗脂肪肝药物中的应用 发明 授权

7. 一种集群式真空冷冻干燥装置 实用新型 授权

8. 一种金钗石斛多糖的提取方法及其应用 发明 授权

9. 一种具有抗肿瘤活性的柠檬果胶酶解产物的制备方法及其应用 发明 授权

1. Zhang MS, Jiang Y, Cheng L, et al. Structural elucidation of lactone derivatives from Dendrobium pendulum. Magn Reson Chem 2023; 61(8): 481-6.

2. Meng YF, Zhang MS, Fang YK, et al. Secondary Metabolites from and Their Activities Induce Metabolites Apoptosis in OSC-19 Cells. Molecules 2023; 28(8).

3. Liu YQ, Lin MS, Mu XR, et al. Protective effect of solanesol in glucose-induced hepatocyte injury: Mechanistic insights on oxidative stress and mitochondrial preservation. Chem-Biol Interact 2023; 383.

4. Huang L, Meng YF, Wang G, et al. Complete ¹H and ¹³C assignments of two new sesquiterpenoids from Dendrobium aduncum. Magn Reson Chem 2023.

5. Zhang MS, Linghu L, Wang G, He YQ, Sun CX, Xiao SJ. Dendrobine-type alkaloids from. Nat Prod Res 2022; 36(21): 5393-9.

6. Li G, Ma XK, Jiang YM, et al. Aqueous two-phase extraction of polysaccharides from

and their bioactivity study. Process Biochem 2022; 118: 274-82.

7. Lei J, Wang YM, Li WW, et al. Natural green deep eutectic solvents-based eco-friendly and efficient extraction of flavonoids from Process optimization, composition identification and biological activity. Sep Purif Technol 2022; 283.

8. Fang YK, Shang ZM, Sun GQ, et al. Glucosyloxybenzyl 2-isobutylmalates and phenolic glycosides from the flowers of. Fitoterapia 2022; 160.

9. Cheng L, Fang YK, He HL, et al. Two New Bibenzyls from. Rec Nat Prod 2022; 16(4): 353-7.

10. Zhang T, Sun GQ, Shuai M, et al. Purification, chemical analysis and inhibitory effects on galectin-3 of enzymatic pH-modified citrus pectin. Food Chem X 2021; 12.

11. Li WW, Dan L, Yao Q, et al. Cardioprotective effects of Amentoflavone by suppression of apoptosis and inflammation on and vivo model of myocardial ischemia-reperfusion injury. Int Immunopharmacol 2021; 101.

12. Lei J, Jiang YM, Luo XR, et al. Ultrasonic-Assisted Ionic Liquid Extraction of Four Biflavonoids from

. Chemistryselect 2021; 6(14): 3297-307.

13. Fang YK, Liu GY, Sun CX, Xiao SJ. A new triterpenoids from. J Asian Nat Prod Res 2021; 23(12): 1204-9.

14. Zhou LM, Ma PC, Shuai M, et al. Analysis of the water-soluble polysaccharides from

pollen and their inhibitory effects on galectin-3 function. Int J Biol Macromol 2020; 159: 455-60.

15. Dong C, Liu Y, Sun CX, et al. Identification of Specific Joint-Inflammatogenic Cell-Free DNA Molecules From Synovial Fluids of Patients With Rheumatoid Arthritis. Frontiers in Immunology 2020; 11.

16. Li D, Sun CX, Yang JQ, et al. Ionic Liquid-Microwave-Based Extraction of Biflavonoids from Selaginella sinensis. Molecules 2019; 24(13).

17. Wu XL, Wu YD, Wang ZY, et al. A Cascade-Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition. Advanced Healthcare Materials 2018; 7(11).

18. Tian HK, He ZY, Sun CX, et al. Uniform Core-Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin. Advanced Healthcare Materials 2018; 7(17).

19. Liu Y, Jiang L, Sun CX, et al. Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nature Communications 2018; 9.

20. Peng B, Lai XY, Chen L, et al. Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability. Acs Omega 2017; 2(9): 6053-62.

21. Sun CX, Li XZ, Liu L, et al. Effect of fasting time on measuring mouse blood glucose level. International Journal of Clinical and Experimental Medicine 2016; 9(2): 4186-9.

22. Sun CX, Jiang L, Liu Y, et al. Adipose Snail1 Regulates Lipolysis and Lipid Partitioning by Suppressing Adipose Triacylglycerol Lipase Expression. Cell Reports 2016; 17(8): 2015-27.

23. Chen Z, Shen H, Sun CX, et al. Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity. American Journal of Physiology-Endocrinology and Metabolism 2015; 308(6): E460-E9.

24. Wang J, Sun CX, Zheng Y, Pan HL, Zhou YF, Fan YY. The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome. Archives of Pharmacal Research 2014; 37(4): 530-8.

25. Sun CX, Chen Y, Li XZ, Tai GH, Fan YY, Zhou YF. Anti-hyperglycemic and anti-oxidative activities of ginseng polysaccharides in STZ-induced diabetic mice. Food & Function 2014; 5(5): 845-8.

丁侃（Team Leader）

杨建文